The movie starts out at Dr. Kimble’s home, where his wife is being murdered by a one-armed man after getting home from a fundraiser she attended with the good doctor. In a flashback, Kimble is seen fighting with the one-armed man. It’s important to note that, while at the fundraiser, Dr. Charles Nichols (Jeroen Krabbé) gives Kimble back his car keys. Kimble is arrested, tried, convicted, and sentenced to death.

Kimble is ordered to await execution at the Menard Correctional Center. We see him and some other convicts loaded on to a bus to take them to Menard. This scene was actually shot in the rear of what is now the Ariel Community Academy. Shooting of the film then moves to North Carolina, even though it is supposed to be Illinois. During their journey on the bus, one of the prisoners fakes being sick and when one of the guard’s heads back to check on him, the guard is jabbed with a needle. A fight ensues leading to the driver getting shot and the bus tumbling down a ravine and into the path of an oncoming train. Kimble helps a seriously wounded guard out the train and himself jumps just before the train hits the bus and derails. Kimble manages to escape the oncoming train. Enter Deputy Samuel Gerard of the U.S. Marshals Service and his team. Kimble makes his way to a hospital, where, after treating his own wounds and shaving his beard, he tells an incoming EMT exactly what’s wrong with the wounded guard before stealing the ambulance. Gerard and his team chase the ambulance to a dam. This is where Kimble and Gerard meet and Kimble jumps off the dam and survives.

Having left the local authorities to find Kimble’s body – alive or dead – Gerard and his team board a plane to head back to Chicago, though the airport terminal seen is Meigs Field, which no longer exists. The runway was demolished March 30, 2003.

After dying his hair and hitchhiking, Kimble makes his way back to Chicago and calls his lawyer for help. He uses a payphone at the Wells Street Bridge. His lawyer says to turn himself in, but he wants to find out who killed his wife and why. So, he tells the lawyer he’s in St. Louis.

Kimble then proceeds to Dr. Nichols’ tennis club, seen as the “North Bank Club.” He intercepts Nichols and gets some money.

Kimble needs somewhere to stay and he finds a basement apartment in a house owned by a Polish woman and her son. The son turns out to be a disgusting criminal and when the police raid the house, they miss Kimble in the basement. This house has either been demolished or heavily altered in the years since the film was made.

After doing that, he finds a photo booth to get photos with which he can doctor the ID and a uniform to wear so he can go back to the hospital. We don’t actually see him exit the thrift shop, but we do see him cross the street at what is this address. When he goes back to get a list of prosthetic arm recipients matching the one-armed man’s description, the victims of a bus crash are being brought in. He sees a little boy in distress. The staff don’t attend to the boy properly. A doctor (Julianne Moore) asks Kimble to bring the boy to observation. While en route, Kimble checks the x-ray and instead fudges orders for surgery. He saves the boys life. But when the aforementioned doctor confronts Kimble, all she does is grab his badge before he runs away.

During the course of their investigation, we see Gerard and his team in a car existing a garage downtown. The building’s address is 50 West Washington Street, though the car exits the garage on N Clark Street.

We see Kimble heading to a jail to question a one-armed prisoner who might be the killer.

Don't mind me, just passing through.

Kimble then runs through Daley plaza.

After running through Daley Plaza, Kimble blends in with the St. Patrick’s Day Parade. The cool thing is that this was shot in the real parade. Kimble dons a green hat and escapes, despite being what appears to be only feet from Gerard. This escape is almost a direct copy of a scene in Alfred Hitchcock’s “The 39 Steps,” though that is not mentioned in any of the commentary on the DVD.

Continuing down the list of one-armed men, Kimble calls a man named Sykes (Katsulas). It turns out Sykes isn’t home.

So, Kimble breaks in and finds that not only is Sykes the killer, Sykes is connected to the Devlin McGregor pharmaceutical company, which hosted the fundraiser seen the night of the murder. Further, Kimble sees Sykes in a photo with another he met that night. He calls Gerard to tell him he’s found a big piece of the puzzle, but doesn’t hang up, allowing Gerard to track the location.

Gerard and his team have already spoken to Dr. Nichols, but need to again, and track him to a pharmaceutical convention being held at the Hilton.

Sykes has been in communication with Nichols, who tells him where to find Kimble. Here, he finds him and follows him on to an L train. The two fight and in the chaos, Sykes shoots a transit cop (Neil Flynn). Eventually, Kimble overpowers Sykes and cuffs him to a railing.

With all of that chaos, the train comes to a stop before entering a station identified as “Balbo,” though it’s really the Clark/Lake station. Kimble busts through a window and we see him go down the platform.

After that, Kimble ditches Sykes' gun in a mailbox at 203 N LaSalle Street.